TCS PrP Inhibitor 13

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TCS PrP Inhibitor 13 是一种抗朊病毒剂，可抑制蛋白酶抗性朊病毒蛋白 (PrP-res) 的积累。

TCS PrP Inhibitor 13 is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.(In Vitro):In Schwannoma cells, administration of 0-500 μM TCS PrP Inhibitor 13 reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and increases expression of cleaved caspase-3 significantly. TCS PrP Inhibitor 13 also significantly reduces the number of proliferating, Ki67-positive cells and total cell number in Schwannoma cells.

TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number.

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5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One

Others

Other Targets

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34320-83-7

281.271

C15H11N3O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (355.53 mM)

[O-][N+](=O)c1ccc(cc1)C1=NN(C(=O)C1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years